Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction
M Kaminska, S Foley, K Maghni… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: The patterns of airway remodeling and the biomarkers that distinguish
different subtypes of severe asthma are unknown. OBJECTIVES: We sought to characterize
subjects with severe asthma with and without chronic persistent airflow obstruction with
respect to airway wall remodeling (histopathologic and radiologic) and specific sputum
biomarkers. METHODS: Subjects with severe asthma with chronic persistent (n= 16) or
intermittent (n= 18) obstruction were studied. Endobronchial biopsy specimens were …
different subtypes of severe asthma are unknown. OBJECTIVES: We sought to characterize
subjects with severe asthma with and without chronic persistent airflow obstruction with
respect to airway wall remodeling (histopathologic and radiologic) and specific sputum
biomarkers. METHODS: Subjects with severe asthma with chronic persistent (n= 16) or
intermittent (n= 18) obstruction were studied. Endobronchial biopsy specimens were …