[HTML][HTML] Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability
SC Wu, Y Zhang - Journal of biological chemistry, 2011 - ASBMB
The H3K27 histone methyltransferase, Ezh2 (enhancer of zeste 2), is a Polycomb group
protein that plays important roles in many biological processes including cellular
differentiation, stem cell biology, and cancer development. Up-regulation of Ezh2 is
observed in various human cancers consistent with its role in cell proliferation. Thus,
understanding the regulation of Ezh2 may reveal how it contributes to the cellular
proliferation process. Here, we demonstrate that Ezh2 can be regulated by the cyclin …
protein that plays important roles in many biological processes including cellular
differentiation, stem cell biology, and cancer development. Up-regulation of Ezh2 is
observed in various human cancers consistent with its role in cell proliferation. Thus,
understanding the regulation of Ezh2 may reveal how it contributes to the cellular
proliferation process. Here, we demonstrate that Ezh2 can be regulated by the cyclin …