PAF-induced death in NMRI mice—a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances
K Becker, G Lueddeckens, R Grupe… - … , leukotrienes and essential …, 1993 - Elsevier
The effects of PAF antagonists, of substances which influence the arachidonic acid
metabolism, and of dexamethasone and ketotifen were evaluated in an acute PAF-induced
mortality model in female NMRI mice. We established a dependence of sensitivity to PAF on
strain (AB mice showed no dose dependence) and on sex of the animals as well as on the
PAF charges used in our experiments. PAF produced resistance in surviving animals
against the PAF-induced death on repeated application. The PAF antagonists, WEB 2170 …
metabolism, and of dexamethasone and ketotifen were evaluated in an acute PAF-induced
mortality model in female NMRI mice. We established a dependence of sensitivity to PAF on
strain (AB mice showed no dose dependence) and on sex of the animals as well as on the
PAF charges used in our experiments. PAF produced resistance in surviving animals
against the PAF-induced death on repeated application. The PAF antagonists, WEB 2170 …