The changing landscape of peripheral T-cell lymphoma in the era of novel therapies
L Karlin, B Coiffier - Seminars in hematology, 2014 - Elsevier
Peripheral T-cell lymphomas (PTCLs) are the most common sub-entity of mature T-cell
lymphomas, and apart from particular presentations, share a poor prognosis with frequent
short-term, agressive, and chemorefractory relapses. Because of the rarity and also the
heterogeneity of the disease, we lack randomized clinical trials. However, to date, neither
intensification of frontline chemotherapy or autologous transplant has led to any
improvement of survival, and the standard CHOP (cyclophosphamide, doxorubicine …
lymphomas, and apart from particular presentations, share a poor prognosis with frequent
short-term, agressive, and chemorefractory relapses. Because of the rarity and also the
heterogeneity of the disease, we lack randomized clinical trials. However, to date, neither
intensification of frontline chemotherapy or autologous transplant has led to any
improvement of survival, and the standard CHOP (cyclophosphamide, doxorubicine …