[HTML][HTML] Fatty acid-binding protein 4, a point of convergence for angiogenic and metabolic signaling pathways in endothelial cells
U Harjes, E Bridges, A McIntyre, BA Fielding… - Journal of Biological …, 2014 - ASBMB
Fatty acid-binding protein 4 (FABP4) is an adipogenic protein and is implicated in
atherosclerosis, insulin resistance, and cancer. In endothelial cells, FABP4 is induced by
VEGFA, and inhibition of FABP4 blocks most of the VEGFA effects. We investigated the
DLL4-NOTCH-dependent regulation of FABP4 in human umbilical vein endothelial cells by
gene/protein expression and interaction analyses following inhibitor treatment and RNA
interference. We found that FABP4 is directly induced by NOTCH. Stimulation of NOTCH …
atherosclerosis, insulin resistance, and cancer. In endothelial cells, FABP4 is induced by
VEGFA, and inhibition of FABP4 blocks most of the VEGFA effects. We investigated the
DLL4-NOTCH-dependent regulation of FABP4 in human umbilical vein endothelial cells by
gene/protein expression and interaction analyses following inhibitor treatment and RNA
interference. We found that FABP4 is directly induced by NOTCH. Stimulation of NOTCH …