[HTML][HTML] Peptides presented by HLA-DR molecules in synovia of patients with rheumatoid arthritis or antibiotic-refractory Lyme arthritis

RJ Seward, EE Drouin, AC Steere… - Molecular & cellular …, 2011 - ASBMB
Disease-associated HLA-DR molecules, which may present autoantigens, constitute the
greatest genetic risk factor for rheumatoid arthritis (RA) and antibiotic-refractory Lyme
arthritis (LA). The peptides presented by HLA-DR molecules in synovia have not previously
been defined. Using tandem mass spectrometry, rigorous database searches, and manual
spectral interpretation, we identified 1,427 HLA-DR-presented peptides (220–464 per
patient) from the synovia of four patients, two diagnosed with RA and two diagnosed with LA …