Commentary on “Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.” Eeles RA, Olama AA, Benlloch S, Saunders EJ …

AF Olumi - Urologic Oncology: Seminars and Original …, 2014 - Elsevier
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To
identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a
custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272
controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer
susceptibility loci were identified at genome-wide significance (P< 5× 10− 8). More than 70
prostate cancer susceptibility loci, explaining~ 30% of the familial risk for this disease, have …