[HTML][HTML] Chimeric granulocyte/macrophage colony-stimulating factor/transforming growth factor-β (TGF-β) receptors define a model system for investigating the role of …

RA Anders, EB Leof - Journal of Biological Chemistry, 1996 - ASBMB
Transforming growth factor-β (TGF-β) belongs to a family of ligands that regulate cell growth
and differentiation. The most commonly observed receptors are referred to as the type I, type
II, and type III (betaglycan) TGF-β receptors. Two receptor models have been presented to
account for the various cellular responses to TGF-β. The first proposes that all TGF-β
signaling results from the formation of a heteromeric type I/type II complex, while the second
suggests that distinct type I or type II TGF-β receptor combinations mediate aspects of TGF-β …