A number of genetic diseases in man have been described in which abnormalities in the
development and function of the lymphatic vascular (LV) system are prominent features. The
genes that are mutated in these diseases are varied and include genes that encode
lymphatic endothelial cell (LEC) growth factor receptors and their ligands and transcription
factors that control LEC fate and function. In addition, an increasing number of genes have
been identified that encode components of the Ras signal transduction pathway that …