The fungal metabolite galiellalactone interferes with the nuclear import of NF-κB and inhibits HIV-1 replication

M Pérez, R Soler-Torronteras, JA Collado… - Chemico-biological …, 2014 - Elsevier
Galiellalactone (GL) is a metabolite produced by the fungus Galiella rufa that presents
antitumor and immunomodulatory activities. GL interferes with the binding to DNA of signal
transducer and activator of transcription (STAT)-3 and also inhibits other signal pathways
such as NF-κB, but the mechanism of action in this pathway remains unknown. In this study
we report that GL inhibits vesicular stomatitis virus-recombinant HIV-1 infection and the NF-
κB-dependent transcriptional activity of the HIV-LTR promoter. We found that GL prevents …