Background The molecular bases of the cellular changes that occur during human
megakaryocyte (MK) ontogeny remain unknown, and may be important for understanding
the significance of MK differentiation from human embryonic stem cells (hESCs) Methods
We optimized the differentiation of MKs from hESCs, and compared these with MKs obtained
from primary human hematopoietic tissues at different stages of development. Results
Transcriptome analyses revealed a close relationship between hESC‐derived and fetal liver …