[HTML][HTML] Analysis of LHX8 mutation in premature ovarian failure
Y Qin, H Zhao, E Kovanci, JL Simpson, ZJ Chen… - Fertility and sterility, 2008 - Elsevier
The LHX8 (LIM homeobox 8) gene encodes a LIM homeodomain transcriptional regulator
that is preferentially expressed in germ cells and critical for mammalian oogenesis. The
authors investigated whether nucleotide changes were present in the LHX8 gene of
Caucasian women with premature ovarian failure (POF), as compared with control women.
When the authors sequenced 95 Caucasian women with POF, they discovered two novel
single-nucleotide polymorphisms (SNPs) in intron 3 (c. 769+ 10G> T) and 3′ untranslated …
that is preferentially expressed in germ cells and critical for mammalian oogenesis. The
authors investigated whether nucleotide changes were present in the LHX8 gene of
Caucasian women with premature ovarian failure (POF), as compared with control women.
When the authors sequenced 95 Caucasian women with POF, they discovered two novel
single-nucleotide polymorphisms (SNPs) in intron 3 (c. 769+ 10G> T) and 3′ untranslated …