Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

LP Jordheim, D Durantel, F Zoulim… - Nature reviews Drug …, 2013 - nature.com
LP Jordheim, D Durantel, F Zoulim, C Dumontet
Nature reviews Drug discovery, 2013nature.com
Nucleoside analogues have been in clinical use for almost 50 years and have become
cornerstones of treatment for patients with cancer or viral infections. The approval of several
additional drugs over the past decade demonstrates that this family still possesses strong
potential. Here, we review new nucleoside analogues and associated compounds that are
currently in preclinical or clinical development for the treatment of cancer and viral infections,
and that aim to provide increased response rates and reduced side effects. We also …
Abstract
Nucleoside analogues have been in clinical use for almost 50 years and have become cornerstones of treatment for patients with cancer or viral infections. The approval of several additional drugs over the past decade demonstrates that this family still possesses strong potential. Here, we review new nucleoside analogues and associated compounds that are currently in preclinical or clinical development for the treatment of cancer and viral infections, and that aim to provide increased response rates and reduced side effects. We also highlight the different approaches used in the development of these drugs and the potential of personalized therapy.
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