Eukaryotic chromosome DNA replication: where, when, and how?

H Masai, S Matsumoto, Z You… - Annual review of …, 2010 - annualreviews.org
H Masai, S Matsumoto, Z You, N Yoshizawa-Sugata, M Oda
Annual review of biochemistry, 2010annualreviews.org
DNA replication is central to cell proliferation. Studies in the past six decades since the
proposal of a semiconservative mode of DNA replication have confirmed the high degree of
conservation of the basic machinery of DNA replication from prokaryotes to eukaryotes.
However, the need for replication of a substantially longer segment of DNA in coordination
with various internal and external signals in eukaryotic cells has led to more complex and
versatile regulatory strategies. The replication program in higher eukaryotes is under a …
DNA replication is central to cell proliferation. Studies in the past six decades since the proposal of a semiconservative mode of DNA replication have confirmed the high degree of conservation of the basic machinery of DNA replication from prokaryotes to eukaryotes. However, the need for replication of a substantially longer segment of DNA in coordination with various internal and external signals in eukaryotic cells has led to more complex and versatile regulatory strategies. The replication program in higher eukaryotes is under a dynamic and plastic regulation within a single cell, or within the cell population, or during development. We review here various regulatory mechanisms that control the replication program in eukaryotes and discuss future directions in this dynamic field.
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