[HTML][HTML] HNF1α inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP-1 and carbohydrate-response element-binding protein …

S Rebouissou, S Imbeaud, C Balabaud… - Journal of biological …, 2007 - ASBMB
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding
hepatocyte nuclear factor 1α (HNF1α) were identified in 50% of hepatocellular adenomas
(HCA) phenotypically characterized by a striking steatosis. To understand the molecular
basis of this aberrant lipid storage, we performed a microarray transcriptome analysis
validated by quantitative reverse transcription-PCR, Western blotting, and lipid profiling. In
mutated HCA, we showed a repression of gluconeogenesis coordinated with an activation of …