Identification of erythroferrone as an erythroid regulator of iron metabolism

L Kautz, G Jung, EV Valore, S Rivella, E Nemeth… - Nature …, 2014 - nature.com
L Kautz, G Jung, EV Valore, S Rivella, E Nemeth, T Ganz
Nature genetics, 2014nature.com
Recovery from blood loss requires a greatly enhanced supply of iron to support expanded
erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin
allows increased iron absorption and mobilization from stores. We identified a new
hormone, erythroferrone (ERFE), that mediates hepcidin suppression during stress
erythropoiesis. ERFE is produced by erythroblasts in response to erythropoietin. ERFE-
deficient mice fail to suppress hepcidin rapidly after hemorrhage and exhibit a delay in …
Abstract
Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores. We identified a new hormone, erythroferrone (ERFE), that mediates hepcidin suppression during stress erythropoiesis. ERFE is produced by erythroblasts in response to erythropoietin. ERFE-deficient mice fail to suppress hepcidin rapidly after hemorrhage and exhibit a delay in recovery from blood loss. ERFE expression is greatly increased in Hbbth3/+ mice with thalassemia intermedia, where it contributes to the suppression of hepcidin and the systemic iron overload characteristic of this disease.
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