Silencing the α2 Subunit of γ-aminobutyric Acid Type A Receptors in Rat Dorsal Root Ganglia Reveals Its Major Role in Antinociception Posttraumatic Nerve Injury
AL Obradovic, J Scarpa, HP Osuru, JL Weaver… - …, 2015 - pubs.asahq.org
Background: Neuropathic pain (NPP) is likely the result of repetitive high-frequency bursts of
peripheral afferent activity leading to long-lasting changes in synaptic plasticity in the spinal
dorsal horn. Drugs that promote γ-aminobutyric acid (GABA) activity in the dorsal horn
provide partial relief of neuropathic symptoms. The authors examined how in vivo silencing
of the GABA receptor type A (GABAA) α2 gene in dorsal root ganglia (DRG) controls NPP.
Methods: After crush injury to the right sciatic nerve of female rats, the α2 GABAA antisense …
peripheral afferent activity leading to long-lasting changes in synaptic plasticity in the spinal
dorsal horn. Drugs that promote γ-aminobutyric acid (GABA) activity in the dorsal horn
provide partial relief of neuropathic symptoms. The authors examined how in vivo silencing
of the GABA receptor type A (GABAA) α2 gene in dorsal root ganglia (DRG) controls NPP.
Methods: After crush injury to the right sciatic nerve of female rats, the α2 GABAA antisense …