Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants
RL Emanuel, JS Torday, N Asokananthan, ME Sunday - Peptides, 2000 - Elsevier
Fetal lung produces corticotropin-releasing hormone (CRH) without known direct effects. We
tested the hypothesis that CRH can directly regulate lung development. In baboon fetal lung
explants, CRH strongly induces surfactant phospholipid synthesis and SP-C
immunostaining, plus [3H] thymidine incorporation. CRH receptor mRNA was detected in
lung from multiple baboons at e125. Testing thyrotropin (TRH) as a specificity control, we did
demonstrate different direct effects with only modest stimulation of surfactant phospholipid …
tested the hypothesis that CRH can directly regulate lung development. In baboon fetal lung
explants, CRH strongly induces surfactant phospholipid synthesis and SP-C
immunostaining, plus [3H] thymidine incorporation. CRH receptor mRNA was detected in
lung from multiple baboons at e125. Testing thyrotropin (TRH) as a specificity control, we did
demonstrate different direct effects with only modest stimulation of surfactant phospholipid …