Learning from animal models of obsessive-compulsive disorder
P Monteiro, G Feng - Biological psychiatry, 2016 - Elsevier
Obsessive-compulsive disorder (OCD) affects 2%–3% of the population worldwide and can
cause significant distress and disability. Substantial challenges remain in the field of OCD
research and therapeutics. Approved interventions alleviate symptoms only partially, with
30%–40% of patients being resistant to treatment. Although the etiology of OCD is still
unknown, research evidence points toward the involvement of cortico-striato-thalamocortical
circuitry. This review focuses on the most recent behavioral, genetics, and neurophysiologic …
cause significant distress and disability. Substantial challenges remain in the field of OCD
research and therapeutics. Approved interventions alleviate symptoms only partially, with
30%–40% of patients being resistant to treatment. Although the etiology of OCD is still
unknown, research evidence points toward the involvement of cortico-striato-thalamocortical
circuitry. This review focuses on the most recent behavioral, genetics, and neurophysiologic …