A set of polyclonal and monoclonal antibodies reveals major differences in post-translational modification of the rat HNF1 and vHNF1 homeoproteins
T Chouard, O Jeannequin, J Rey-Campos, M Yaniv… - Biochimie, 1997 - Elsevier
The related homeodomain-containing transcription factors HNF1 (HNF1α) and vHNF1
(HNF1β) recognise common target DNA sequences in the regulatory regions of many genes
and are expressed in several parenchymal cell types, predominantly in liver, kidney,
intestine and pancreas. HNFI-mull mutant mice, with a wild-type vHNF1 gene, develop
normally, but die within a few weeks of birth with severe liver and kidney failure. Humans
with a mutation in the HNF1α gene develop non-insulin dependent diabetes on maturity …
(HNF1β) recognise common target DNA sequences in the regulatory regions of many genes
and are expressed in several parenchymal cell types, predominantly in liver, kidney,
intestine and pancreas. HNFI-mull mutant mice, with a wild-type vHNF1 gene, develop
normally, but die within a few weeks of birth with severe liver and kidney failure. Humans
with a mutation in the HNF1α gene develop non-insulin dependent diabetes on maturity …