Time to evolve trial design after everolimus failure

JM Llovet - Nature reviews Clinical oncology, 2014 - nature.com
Nature reviews Clinical oncology, 2014nature.com
Hepatocellular carcinoma is a difficult-to-treat cancer and, after numerous phase III trials
assessing kinase inhibitors have failed to meet their end points, sorafenib is the only
accepted treatment for advanced stages of the disease. Now, the trial EVOLVE-1 has shown
a lack of benefit for everolimus in the second-line treatment setting.
Hepatocellular carcinoma is a difficult-to-treat cancer and, after numerous phase III trials assessing kinase inhibitors have failed to meet their end points, sorafenib is the only accepted treatment for advanced stages of the disease. Now, the trial EVOLVE-1 has shown a lack of benefit for everolimus in the second-line treatment setting.
nature.com