Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation
KH Weylandt, CY Chiu, B Gomolka… - Prostaglandins & other …, 2012 - Elsevier
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have long been associated with
decreased inflammation and are also implicated in the prevention of tumorigenesis.
Conventional thinking attributed this mainly to a suppressive effect of these fatty acids on the
formation of arachidonic acid-derived prostaglandins and leukotrienes. Recent years have
seen the discovery of a new class of inflammation-dampening and resolution-promoting n-3
PUFA-derived lipid mediators called resolvins and protectins. Chemically, these compounds …
decreased inflammation and are also implicated in the prevention of tumorigenesis.
Conventional thinking attributed this mainly to a suppressive effect of these fatty acids on the
formation of arachidonic acid-derived prostaglandins and leukotrienes. Recent years have
seen the discovery of a new class of inflammation-dampening and resolution-promoting n-3
PUFA-derived lipid mediators called resolvins and protectins. Chemically, these compounds …