[HTML][HTML] Synthetically defined glycoprotein vaccines: current status and future directions

R Adamo, A Nilo, B Castagner, O Boutureira, F Berti… - Chemical …, 2013 - pubs.rsc.org
Chemical science, 2013pubs.rsc.org
Primary examples in vaccine design have shown good levels of carbohydrate-specific
antibody generation when raised using extracted or fully synthetic capsular polysaccharide
glycans covalently coupled to a protein carrier. Herein, we cover recent clinical
developments of carbohydrate-based vaccines and describe how novel cutting-edge
methodology for the total synthesis of oligosaccharides and for the precise placement of
carbohydrates at pre-determined sites within a protein may be used to further improve the …
Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.
The Royal Society of Chemistry