Convergence of two independent mental disease genes on the protein level: recruitment of dysbindin to cell-invasive disrupted-in-schizophrenia 1 aggresomes

P Ottis, V Bader, SV Trossbach, H Kretzschmar… - Biological …, 2011 - Elsevier
BACKGROUND: Both disrupted-in-schizophrenia 1 (DISC1) and dysbindin have been
identified as schizophrenia candidate genes in independent genetic linkage studies. The
proteins have been assigned distinct subcellular locations and functions. We investigated
whether both proteins converge into a common pathway specific for schizophrenia or mental
diseases. METHODS: DISC1 and dysbindin were expressed as recombinant proteins with or
without a fluorescent protein-tag in human or mouse neuroblastoma cells and as …