[HTML][HTML] Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus

H Esterbauer, H Oberkofler, YM Liu, D Breban… - Journal of lipid …, 1998 - ASBMB
Abstract Uncoupling protein-1 (UCP-1) activity in brown adipose tissue increases
thermogenesis, contributes to facultative energy expenditure in humans, and has been
implicated in the pathogenesis of rodent obesity. To determine genetic factors controlling
UCP-1 expression in humans, we measured intra-and extraperitoneal UCP-1 mRNA
abundance levels by a competitive RT-PCR method and compared expression levels with
common sequence variations in the β3-adrenergic receptor gene and the distal UCP-1 gene …