[HTML][HTML] Lysophosphatidic acid initiates epithelial to mesenchymal transition and induces β-catenin-mediated transcription in epithelial ovarian carcinoma
RJ Burkhalter, SD Westfall, Y Liu, MS Stack - Journal of Biological …, 2015 - ASBMB
During tumor progression, epithelial ovarian cancer (EOC) cells undergo epithelial-to-
mesenchymal transition (EMT), which influences metastatic success. Mutation-dependent
activation of Wnt/β-catenin signaling has been implicated in gain of mesenchymal
phenotype and loss of differentiation in several solid tumors; however, similar mutations are
rare in most EOC histotypes. Nevertheless, evidence for activated Wnt/β-catenin signaling in
EOC has been reported, and immunohistochemical analysis of human EOC tumors …
mesenchymal transition (EMT), which influences metastatic success. Mutation-dependent
activation of Wnt/β-catenin signaling has been implicated in gain of mesenchymal
phenotype and loss of differentiation in several solid tumors; however, similar mutations are
rare in most EOC histotypes. Nevertheless, evidence for activated Wnt/β-catenin signaling in
EOC has been reported, and immunohistochemical analysis of human EOC tumors …