[HTML][HTML] Transition from rolling to firm adhesion can be mimicked by extension of integrin αLβ2 in an intermediate affinity state

A Salas, M Shimaoka, U Phan, M Kim… - Journal of biological …, 2006 - ASBMB
α L β 2 affinity for intercellular adhesion molecule-1 (ICAM-1) is regulated by the
conformation of the α LI domain, which is in turn controlled by the conformation and
orientation of other adjacent domains. Additionally, overall integrin conformation (bent
versus straightened) influences the orientation of the I domain and access to its ligands,
influencing adhesive efficiency. The open or high affinity I domain conformation supports
strong adhesion, whereas the closed, low affinity conformation mediates weak interactions …