If the large collection of microarray-specific statistical tools was applicable to the analysis of
quantitative shotgun proteomics datasets, it would certainly foster an important advancement
of proteomics research. Here we analyze two large multidimensional protein identification
technology datasets, one containing eight replicates of the soluble fraction of a yeast whole-
cell lysate and one containing nine replicates of a human immunoprecipitate, to test whether
normalized spectral abundance factor (NSAF) values share substantially similar statistical …