The ground substance of the arterial wall Part 1. Extractability of glycosammoglycans and the isolation of a proteoglycan from bovine aorta

R Eisenstein, SE Larsson, KE Kuettner… - …, 1975 - atherosclerosis-journal.com
Water and glycosaminoglycan contents were measured in upper and lower thoracic aortas
of calves and steers. The ability of various molarities of guanidine hydrochloride to extract
glycosaminoglycans from these tissues was assessed. Some glycosaminoglycans seem to
be more resistant to extraction than others. A procedure is described for the isolation of a
proteoglycan. The molecule appears to contain both dermatan sulfate and chondroitin
sulfate. It also seems to be less dense than cartilage proteoglycans extracted by similar …