OBJECTIVE: Macrophages are decisive in the chronic inflammatory processes that drive
atherogenesis. The purpose of this study was to explore the presence and spatial
distribution of polarized macrophage populations in human atherosclerosis. METHODS &
RESULTS: We used transcriptomics and immunohistochemistry to analyze macrophage
subset dynamics in successive stages of atherogenesis. Developing lesions progressively
accumulated both M1 and M2 cells, as was signified by the enhanced expression of …