[HTML][HTML] Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP α2-chimaerin
F Colón-González, FC Leskow… - Journal of biological …, 2008 - ASBMB
Chimaerins are a family of GTPase activating proteins (GAPs) for the small G-protein Rac
that have gained recent attention due to their important roles in development, cancer,
neuritogenesis, and T-cell function. Like protein kinase C isozymes, chimaerins possess a
C1 domain capable of binding phorbol esters and the lipid second messenger diacylglycerol
(DAG) in vitro. Here we identified an autoinhibitory mechanism in α2-chimaerin that restricts
access of phorbol esters and DAG, thereby limiting its activation. Although phorbol 12 …
that have gained recent attention due to their important roles in development, cancer,
neuritogenesis, and T-cell function. Like protein kinase C isozymes, chimaerins possess a
C1 domain capable of binding phorbol esters and the lipid second messenger diacylglycerol
(DAG) in vitro. Here we identified an autoinhibitory mechanism in α2-chimaerin that restricts
access of phorbol esters and DAG, thereby limiting its activation. Although phorbol 12 …