[HTML][HTML] The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human …

M Guha, N Mackman - Journal of Biological Chemistry, 2002 - ASBMB
Monocytes and macrophages express cytokines and procoagulant molecules in various
inflammatory diseases. In sepsis, lipopolysaccharide (LPS) from Gram-negative bacteria
induces tumor necrosis factor-alpha (TNF-α) and tissue factor (TF) in monocytic cells via the
activation of the transcription factors Egr-1, AP-1, and nuclear factor-κB. However, the
signaling pathways that negatively regulate LPS-induced TNF-α and TF expression in
monocytic cells are currently unknown. We report that inhibition of the phosphatidylinositol 3 …