Expansion of CD19hiCD21lo/neg B cells in common variable immunodeficiency (CVID) patients with autoimmune cytopenia

K Warnatz, C Wehr, R Dräger, S Schmidt, H Eibel… - Immunobiology, 2002 - Elsevier
Common variable immunodeficiency (CVID) is characterized by a severe
hypogammaglobulinemia. While the clinical picture is dominated by recurrent respiratory
and gastrointestinal infections, a subgroup of up to 30% of the patients develops additional
autoimmune phenomena, including thrombocytopenia and autoimmune hemolytic anemia.
So far no classification allowed a prediction of the coincidence of immunodeficiency and
autoimmunity. Here, we propose the size of the peripheral CD19hiCD21lo/neg B cell pool as …