Heparin-induced thrombocytopenia in medical surgical critical illness
TE Warkentin, JAI Sheppard, D Heels-Ansdell… - Chest, 2013 - Elsevier
Background In a recent multicenter randomized trial comparing unfractionated heparin
(UFH) with low-molecular-weight heparin (dalteparin) for thromboprophylaxis in 3,746
critically ill patients, 17 patients (0.5%) developed heparin-induced thrombocytopenia (HIT)
based on serotonin-release assay-positive (SRA+) status. A trend to a lower frequency of
HIT with dalteparin vs UFH was observed in the intention-to-treat analysis (five vs 12
patients, P=. 14), which was statistically significant (three vs 12 patients, P=. 046) in a …
(UFH) with low-molecular-weight heparin (dalteparin) for thromboprophylaxis in 3,746
critically ill patients, 17 patients (0.5%) developed heparin-induced thrombocytopenia (HIT)
based on serotonin-release assay-positive (SRA+) status. A trend to a lower frequency of
HIT with dalteparin vs UFH was observed in the intention-to-treat analysis (five vs 12
patients, P=. 14), which was statistically significant (three vs 12 patients, P=. 046) in a …