[HTML][HTML] Role of laminin terminal globular domains in basement membrane assembly

KK McKee, D Harrison, S Capizzi… - Journal of Biological …, 2007 - ASBMB
Laminins contribute to basement membrane assembly through interactions of their N-and C-
terminal globular domains. To further analyze this process, recombinant laminin-111
heterotrimers with deletions and point mutations were generated by recombinant expression
and evaluated for their ability to self-assemble, interact with nidogen-1 and type IV collagen,
and form extracellular matrices on cultured Schwann cells by immunofluorescence and
electron microscopy. Wild-type laminin and laminin without LG domains polymerized in …