Depletion and reconstitution of macrophages in mice

SB Weisser, N van Rooijen, LM Sly - JoVE (Journal of Visualized …, 2012 - jove.com
Macrophages are critical players in the innate immune response to infectious challenge or
injury, initiating the innate immune response and directing the acquired immune response.
Macrophage dysfunction can lead to an inability to mount an appropriate immune response
and as such, has been implicated in many disease processes, including inflammatory bowel
diseases. Macrophages display polarized phenotypes that are broadly divided into two
categories. Classically activated macrophages, activated by stimulation with IFNγ or LPS …