A minimal domain responsible for Munc13 activity
J Basu, N Shen, I Dulubova, J Lu, R Guan… - Nature structural & …, 2005 - nature.com
Nature structural & molecular biology, 2005•nature.com
Munc13 proteins are essential in neurotransmitter release, controlling the priming of
synaptic vesicles to a release-ready state. The sequences responsible for this priming
activity are unknown. Here we identify a large α-helical domain of mammalian Munc13-1
that is autonomously folded and is sufficient to rescue the total arrest in neurotransmitter
release observed in hippocampal neurons lacking Munc13s.
synaptic vesicles to a release-ready state. The sequences responsible for this priming
activity are unknown. Here we identify a large α-helical domain of mammalian Munc13-1
that is autonomously folded and is sufficient to rescue the total arrest in neurotransmitter
release observed in hippocampal neurons lacking Munc13s.
Abstract
Munc13 proteins are essential in neurotransmitter release, controlling the priming of synaptic vesicles to a release-ready state. The sequences responsible for this priming activity are unknown. Here we identify a large α-helical domain of mammalian Munc13-1 that is autonomously folded and is sufficient to rescue the total arrest in neurotransmitter release observed in hippocampal neurons lacking Munc13s.
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