[HTML][HTML] Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function

CS Lee, DK Georgiou, A Dagnino-Acosta, J Xu… - Journal of Biological …, 2014 - ASBMB
Rapamycin at high doses (2–10 mg/kg body weight) inhibits mammalian target of rapamycin
complex 1 (mTORC1) and protein synthesis in mice. In contrast, low doses of rapamycin (10
μg/kg) increase mTORC1 activity and protein synthesis in skeletal muscle. Similar changes
are found with SLF (synthetic ligand for FKBP12, which does not inhibit mTORC1) and in
mice with a skeletal muscle-specific FKBP12 deficiency. These interventions also increase
Ca 2+ influx to enhance refilling of sarcoplasmic reticulum Ca 2+ stores, slow muscle …