Abnormal intrafusal muscle fibres in myotonic dystrophy: a study using serial sections

M Swash, KP Fox - Journal of Neurology, Neurosurgery & Psychiatry, 1975 - jnnp.bmj.com
M Swash, KP Fox
Journal of Neurology, Neurosurgery & Psychiatry, 1975jnnp.bmj.com
Studies of the extent and complexity of intrafusal muscle fibre splitting in myotonic dystrophy
have been carried out in three spindles obtained at muscle biopsy, and in nine spindles
found in the lumbrical muscle of a case that came to necropsy. It is suggested that splitting,
due to mechanical stresses, leads to a regenerative response in the separated fragments.
Studies of the extent and complexity of intrafusal muscle fibre splitting in myotonic dystrophy have been carried out in three spindles obtained at muscle biopsy, and in nine spindles found in the lumbrical muscle of a case that came to necropsy. It is suggested that splitting, due to mechanical stresses, leads to a regenerative response in the separated fragments.
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