[HTML][HTML] Characterization of graf, the GTPase-activating protein for rho associated with focal adhesion kinase: Phosphorylation and possible regulation by mitogen …
JM Taylor, JD Hildebrand, CP Mack, ME Cox… - Journal of Biological …, 1998 - ASBMB
Graf is a GTPase-activating protein for Rho that interacts with focal adhesion kinase and co-
localizes with the actin cytoskeleton (Hildebrand, JD, Taylor, JM and Parsons, JT (1996) Mol.
Cell. Biol. 16, 3169–3178). We examined the expression and regulation of Graf as a prelude
to understanding the role of Graf in mediating signal transductionin vivo. We demonstrated
that Graf is a ubiquitously expressed 95-kDa protein with high levels observed in heart and
brain and cells derived from these tissues. Stimulation of PC12 cells with epidermal growth …
localizes with the actin cytoskeleton (Hildebrand, JD, Taylor, JM and Parsons, JT (1996) Mol.
Cell. Biol. 16, 3169–3178). We examined the expression and regulation of Graf as a prelude
to understanding the role of Graf in mediating signal transductionin vivo. We demonstrated
that Graf is a ubiquitously expressed 95-kDa protein with high levels observed in heart and
brain and cells derived from these tissues. Stimulation of PC12 cells with epidermal growth …