Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease

KN Theken, RN Schuck, ML Edin, B Tran, K Ellis… - Atherosclerosis, 2012 - Elsevier
OBJECTIVE: Preclinical and genetic epidemiologic studies suggest that modulating
cytochrome P450 (CYP)-mediated arachidonic acid metabolism may have therapeutic utility
in the management of coronary artery disease (CAD). However, predictors of inter-individual
variation in CYP-derived eicosanoid metabolites in CAD patients have not been evaluated
to date. Therefore, the primary objective was to identify clinical factors that influence CYP
epoxygenase, soluble epoxide hydrolase (sEH), and CYP ω-hydroxylase metabolism in …