Experimental models of painful diabetic neuropathy

NA Calcutt - Journal of the neurological sciences, 2004 - jns-journal.com
Diabetes mellitus is one of the most rapidly growing health concerns in the developed world
due to the persistence of type 1 (insulin-deficient) diabetes and the dramatic increase in type
2 (insulin-resistant) diabetes that is secondary to changes of diet and lifestyle in the
population [1]. Hyperglycemia is the primary pathophysiologic mechanism common to both
types of diabetes mellitus, and elevated blood and tissue sugar levels have been associated
with the development of the secondary complications of diabetes that lead to the increased …