Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular
function. Its actions are mediated through an abundant class of specific binding sites that
activate adenylyl cyclase through a G protein-coupled mechanism. We report here the
identification of a cDNA clone for the adrenomedullin receptor that was originally isolated as
an orphan receptor from rat lung. The cDNA encodes a polypeptide of 395 residues that
contains seven transmembrane domains and has a general structural resemblance to other …