[HTML][HTML] ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases
MA Olayioye, I Beuvink, K Horsch, JM Daly… - Journal of Biological …, 1999 - ASBMB
Epidermal growth factor (EGF) binding to its receptor, ErbB1, triggers various signal
transduction pathways, one of which leads to the activation of signal transducer and
activator of transcription (Stat) factors. The mechanism underlying ErbB1-induced Stat
activation and whether Stats are downstream targets of other ErbB receptors have not been
explored. In this report we show that ErbB2, ErbB3, and ErbB4 do not potentiate Stat5
phosphorylation by EGF. However, neu differentiation factor-induced heterodimers of ErbB2 …
transduction pathways, one of which leads to the activation of signal transducer and
activator of transcription (Stat) factors. The mechanism underlying ErbB1-induced Stat
activation and whether Stats are downstream targets of other ErbB receptors have not been
explored. In this report we show that ErbB2, ErbB3, and ErbB4 do not potentiate Stat5
phosphorylation by EGF. However, neu differentiation factor-induced heterodimers of ErbB2 …