Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion
SS Rho, HJ Choi, JK Min, HW Lee, H Park… - Biochemical and …, 2011 - Elsevier
Biochemical and biophysical research communications, 2011•Elsevier
Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been
determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells
(ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed
that Clec14a mediates cell–cell adhesion through its C-type lectin-like domain. Knockdown
of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed
formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC …
determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells
(ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed
that Clec14a mediates cell–cell adhesion through its C-type lectin-like domain. Knockdown
of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed
formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC …
Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells (ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed that Clec14a mediates cell–cell adhesion through its C-type lectin-like domain. Knockdown of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC-specific protein that appears to play a role in cell–cell adhesion and angiogenesis.
Elsevier