[HTML][HTML] AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1
AI Muir, L Chamberlain, NA Elshourbagy… - Journal of Biological …, 2001 - ASBMB
A novel human G protein-coupled receptor named AXOR12, exhibiting 81% homology to the
rat orphan receptor GPR54, was cloned from a human brain cDNA library. Heterologous
expression of AXOR12 in mammalian cells permitted the identification of three surrogate
agonist peptides, all with a common C-terminal amidated motif. High potency agonism,
indicative of a cognate ligand, was evident from peptides derived from the gene KiSS-1, the
expression of which prevents metastasis in melanoma cells. Quantitative reverse …
rat orphan receptor GPR54, was cloned from a human brain cDNA library. Heterologous
expression of AXOR12 in mammalian cells permitted the identification of three surrogate
agonist peptides, all with a common C-terminal amidated motif. High potency agonism,
indicative of a cognate ligand, was evident from peptides derived from the gene KiSS-1, the
expression of which prevents metastasis in melanoma cells. Quantitative reverse …