[PDF][PDF] T-cell-depleted reduced-intensity transplantation followed by donor leukocyte infusions to promote graft-versus-lymphoma activity results in excellent long-term …

KJ Thomson, EC Morris, D Milligan, AN Parker… - J Clin …, 2010 - researchgate.net
KJ Thomson, EC Morris, D Milligan, AN Parker, AE Hunter, G Cook, AJ Bloor, F Clark…
J Clin Oncol, 2010researchgate.net
Purpose Follicular lymphoma (FL) is an indolent disorder that is treatable but considered
incurable with chemotherapy alone. The curative potential of allogeneic transplantation
using conventional myeloablative conditioning has been demonstrated, but this approach is
precluded in the majority of patients with FL because of excessive toxicity. Thus, reduced-
intensity conditioning regimens are being explored.
Purpose
Follicular lymphoma (FL) is an indolent disorder that is treatable but considered incurable with chemotherapy alone. The curative potential of allogeneic transplantation using conventional myeloablative conditioning has been demonstrated, but this approach is precluded in the majority of patients with FL because of excessive toxicity. Thus, reduced-intensity conditioning regimens are being explored.
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