The pro-protein convertase PC1 is induced in the transected sciatic nerve and is present in cultured Schwann cells: comparison with PC5, furin and PC7, implication in …
M Marcinkiewicz, D Savaria, J Marcinkiewicz - Molecular brain research, 1998 - Elsevier
Injury of peripheral nerves induces expression of several pro-protein convertases (PCs)
involved in processing of precursor proteins into their diverse active end-products. In this
study, the focus was on convertase PC1 which, although undetectable in control nerves, is
strongly induced in injured nerves. High concentrations of PC1 mRNA of 9.0, 5.5, 3.0, 2.5
and 1.6 kb were observed on day 4 post-lesion in proximal and distal segments. By in situ
hybridization PC1 mRNA was detected in most of endoneurial cells, which were further …
involved in processing of precursor proteins into their diverse active end-products. In this
study, the focus was on convertase PC1 which, although undetectable in control nerves, is
strongly induced in injured nerves. High concentrations of PC1 mRNA of 9.0, 5.5, 3.0, 2.5
and 1.6 kb were observed on day 4 post-lesion in proximal and distal segments. By in situ
hybridization PC1 mRNA was detected in most of endoneurial cells, which were further …