Peptides associated with hyperphagia in adults with Prader–Willi syndrome before and during GH treatment

C Höybye, B Barkeling, U Espelund… - Growth Hormone & IGF …, 2003 - Elsevier
Prader–Willi syndrome (PWS) is a complex genetic disorder characterised by mild mental
retardation and distinct physical, behavioural, and psychiatric features. One of the cardinal
symptoms is excessive eating, which–if left untreated–leads to extreme obesity. In the
present study we have examined circulating levels of peptides with documented association
to hyperphagia in young adults with PWS. Since growth hormone (GH) is often used
nowadays to correct GH insufficiency during childhood PWS, we also studied the impact of …