[HTML][HTML] Choriocapillaris breakdown precedes retinal degeneration in age-related macular degeneration

A Biesemeier, T Taubitz, S Julien, E Yoeruek… - Neurobiology of …, 2014 - Elsevier
A Biesemeier, T Taubitz, S Julien, E Yoeruek, U Schraermeyer
Neurobiology of aging, 2014Elsevier
This work presents a combined light and electron microscopical approach to investigate the
initial breakdown of the retinal pigment epithelium (RPE) and choriocapillaris (CC) in age-
related macular degeneration (AMD). Perimacular sections of 12 dry and wet AMD eyes
(82±15 years) and 7 age-matched controls (75±10 years) without retinal pathology were
investigated. Disease progression was classified into 5 stages of retinal degeneration to
investigate the concurrent CC breakdown. Special emphasis was laid on transitions where …
Abstract
This work presents a combined light and electron microscopical approach to investigate the initial breakdown of the retinal pigment epithelium (RPE) and choriocapillaris (CC) in age-related macular degeneration (AMD). Perimacular sections of 12 dry and wet AMD eyes (82 ± 15 years) and 7 age-matched controls (75 ± 10 years) without retinal pathology were investigated. Disease progression was classified into 5 stages of retinal degeneration to investigate the concurrent CC breakdown. Special emphasis was laid on transitions where intact CC–RPE–retina complexes went over into highly atrophied areas. AMD sections showed elevated loss of photoreceptors, RPE and CC (p < 0.01), and thickened Bruch's membrane with increased basal laminar and linear deposits compared with controls. Up to 27% of the CC was lost in controls although RPE and retina were still intact. This primary loss of CC further increased with AMD (up to 100%). The data implicate that CC breakdown already occurs during normal aging and precedes degeneration of the RPE and retina with AMD, defining AMD as a vascular disease. Particular attention should be given to the investigation of early AMD stages and transitional stages to the late stage that reveal a possible sequence of degenerative steps with aging and AMD.
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